Gene name:
NR3C2 (MCR;MLR) ;
Protein name:
Mineralocorticoid receptor (MR) ;
Alternative:
Nuclear receptor subfamily 3 group C member 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, NCOA2, TIF1 and NRIP1.
Function:
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Subcellular Location:
Cytoplasm
Nucleus
Endoplasmic reticulum membrane
Peripheral membrane protein
Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Protein Attributes:
50:
METKGYHSLP | EGLDMERRWG | QVSQAVERSS | LGPTERTDEN | NYMEIVNVSC |
100:
VSGAIPNNST | QGSSKEKQEL | LPCLQQDNNR | PGILTSDIKT | ELESKELSAT |
150:
VAESMGLYMD | SVRDADYSYE | QQNQQGSMSP | AKIYQNVEQL | VKFYKGNGHR |
200:
PSTLSCVNTP | LRSFMSDSGS | SVNGGVMRAI | VKSPIMCHEK | SPSVCSPLNM |
250:
TSSVCSPAGI | NSVSSTTASF | GSFPVHSPIT | QGTPLTCSPN | AENRGSRSHS |
300:
PAHASNVGSP | LSSPLSSMKS | SISSPPSHCS | VKSPVSSPNN | VTLRSSVSSP |
350:
ANINNSRCSV | SSPSNTNNRS | TLSSPAASTV | GSICSPVNNA | FSYTASGTSA |
400:
GSSTLRDVVP | SPDTQEKGAQ | EVPFPKTEEV | ESAISNGVTG | QLNIVQYIKP |
450:
EPDGAFSSSC | LGGNSKINSD | SSFSVPIKQE | STKHSCSGTS | FKGNPTVNPF |
500:
PFMDGSYFSF | MDDKDYYSLS | GILGPPVPGF | DGNCEGSGFP | VGIKQEPDDG |
550:
SYYPEASIPS | SAIVGVNSGG | QSFHYRIGAQ | GTISLSRSAR | DQSFQHLSSF |
600:
PPVNTLVESW | KSHGDLSSRR | SDGYPVLEYI | PENVSSSTLR | SVSTGSSRPS |
650:
KICLVCGDEA | SGCHYGVVTC | GSCKVFFKRA | VEGQHNYLCA | GRNDCIIDKI |
700:
RRKNCPACRL | QKCLQAGMNL | GARKSKKLGK | LKGIHEEQPQ | QQQPPPPPPP |
750:
PQSPEEGTTY | IAPAKEPSVN | TALVPQLSTI | SRALTPSPVM | VLENIEPEIV |
800:
YAGYDSSKPD | TAENLLSTLN | RLAGKQMIQV | VKWAKVLPGF | KNLPLEDQIT |
850:
LIQYSWMCLS | SFALSWRSYK | HTNSQFLYFA | PDLVFNEEKM | HQSAMYELCQ |
900:
GMHQISLQFV | RLQLTFEEYT | IMKVLLLLST | IPKDGLKSQA | AFEEMRTNYI |
950:
KELRKMVTKC | PNNSGQSWQR | FYQLTKLLDS | MHDLVSDLLE | FCFYTFRESH |
984:
ALKVEFPAML | VEIISDQLPK | VESGNAKPLY | FHRK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Chicken
Pig
Polyclonal Antibody for Human MR
Polyclonal Antibody for Human MR
Polyclonal Antibody for Human MR
Polyclonal Antibody for Human MR
Polyclonal Antibody for Human MR
Monoclonal Antibody for Human MR
Monoclonal Antibody for Human MR
Monoclonal Antibody for Human MR
Monoclonal Antibody for Human MR
Monoclonal Antibody for Human MR
R&D Technical Data
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Precision
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Recovery
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Linearity
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[
Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] GLN-7
27.
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Cited for : VARIANTS PHA1A SER-645; SER-659; SER-759; PRO-769; LYS-770; PRO-805 AND ARG-815